Work

Moesin strikes an “Actin”g balance to regulate osteoclast fusion and activity

Year: 2025

Type: article

Abstract: Key aspects of osteoclast fusion and its coupling with bone resorption activity are lacking. In this issue, Dufrancias and colleagues (https://doi.org/10.1083/jcb.202409169) shed new light on the mechanism underpinning osteoclast fusion and activity, highlighting the critical role of the ERM family member moesin in this important process.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202509068

Authors: Marwa Zeyad, Yousef Abu-Amer

Institutions: Washington University in St. Louis, Shriners Hospitals for Children - St. Louis

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Shriners Hospitals for Children, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G4247006901, G9000004556, G9000282325, Development of Injectable Super-Lubricious Microgels for Sustained Release of Platelet-Rich Plasma to Treat Post-Traumatic Osteoarthritis