Benign but bizarre: A case report on idiopathic scrotal calcinosis
Year: 2025
Type: article
Study design: Case Report
Abstract: Calcinosis cutis, also known as calcification in soft tissue, is an uncommon benign condition that can be further classified into idiopathic, dystrophic, iatrogenic, metastatic, and calciphylaxis subtypes. The scrotum is one area where calcinosis cutis frequently occurs. During years or decades, the nodules gradually enlarge. The scrotal calcinosis cutis ca be solitary or multiple, typically asymptomatic, hard, yellowish marble-like, polypoidal. Despite being a benign, patients with this condition present late due to shyness or cancer anxiety, even when faced with sexual discomfort and infertility. In this article, we want to raise awareness to highlight benignity of this condition, various treatment options and good prognosis associate with the disease. A 38-year-old male presented with multiple painful, itchy scrotal swellings and infertility. Examination revealed scrotal nodules, absent left testis, and aspermia. Histopathology confirmed scrotal calcinosis. Total scrotectomy was performed with right testis repositioned in the thigh. Patient was referred for infertility management after successful surgical recovery. Idiopathic calcinosis cutis of the scrotum (ICCS) is a benign, slow-growing condition often presenting in adulthood with asymptomatic yellowish nodules. Diagnosis is confirmed histologically. Though idiopathic, it may involve dystrophic calcification of epidermoid cysts. Surgical excision with scrotal reconstruction is the preferred treatment, offering excellent cosmetic and curative outcomes. Being usually asymptomatic, ICCS is a benign disorder. It appears as a series of successive, different-sized nodules. A histological evaluation shows the calcified regions. One of two possible causes exists: idiopathic or dystrophic calcification of cysts. Excision is the preferred course of action. • Definition and Rarity: Calcinosis cutis refers to abnormal calcium deposits in the skin, with idiopathic scrotal calcinosis (ICCS) being a rare and typically benign condition presenting as asymptomatic nodules on the scrotum. • Case Summary: A 38-year-old male presented with multiple hard, yellowish nodules on the scrotum for 10 years, causing discomfort and fertility issues. Imaging showed aspermia and an absent left testis. Histopathology confirmed scrotal calcinosis. • Treatment: Total scrotectomy was performed with right testis repositioned in a thigh pocket, and a negative suction drain was used to prevent fluid accumulation. • Pathophysiology Debate: The origin of ICCS is debated—some believe it’s idiopathic, while others argue it results from dystrophic calcification of epidermoid or follicular cysts. • Diagnosis and Management: Diagnosis is confirmed histologically. Treatment is surgical excision with scrotal reconstruction, offering good cosmetic results and preventing recurrence.
Authors: Amol Gupta, Sanjeev Gianchandani, Swati Deshpande, Vasundhara Gopalan, Jhanwi Khurana, Arushi Kaul
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,090
OpenAlex ID: W4415610467