Post-Herpetic Neuralgia: Review of Pathophysiology, Mechanisms, and Drug Treatment
Year: 2025
Type: article
Abstract: Post-herpetic neuralgia (PHN) is the most common complication of Herpes zoster infection. Although numerous targeted therapeutic drugs have been developed, it is difficult to achieve a complete cure. Abnormalities in neural circuits, ion channels, inflammatory factors, and gene regulation are crucial factors contributing to the development of PNH; however, the underlying mechanism remains unclear. Therefore, a comprehensive understanding of the underlying mechanisms of PNH is critical for advancing research and developing novel therapeutic strategies. Based on the latest findings, we systematically reviewed the current understanding of PHN mechanisms and corresponding treatment options and provided a comprehensive reference for future studies.
Source: Current Neuropharmacology
Authors: Xin Yan, Yufan He, Yuwan Yue, Chuan Zhang, Hanfeng Yang, Peilin Zhao
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4415612013