MET-Driven Resistance to Sotorasib in KRAS G12C–Mutant NSCLC and Response to Combined KRAS and MET Inhibition
Year: 2025
Type: article
Abstract: Introduction: amplification has been described as a putative off-target resistance mechanism, although its clinical relevance remains incompletely understood. Methods: fluorescence in situ hybridization. Results: amplification achieved a renewed partial response to the combination of sotorasib and tepotinib after progression on sotorasib monotherapy. Conclusion: amplification as a resistance mechanism and to define optimal therapeutic thresholds for combined KRAS and MET inhibition.
Authors: Richard Riedel, Lea Ruge, Malte Verheyen, Felix John, Heather Scharpenseel, Lucia Nogova, Sebastian Michels, Rieke N. Fischer, Anna Eisert, Carolin Jakob, Emanuel Niesen, Jana Fassunke, Janna Siemanowski-Hrach, Carina Heydt, Anne Bunck, Udo Siebolts, Sabine Merkelbach-Bruse, Reinhard Buettner, Jürgen Wolf, Matthias Scheffler
Institutions: University of Cologne, University Hospital Cologne
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W4415612293