Work

Differential increase in endocannabinoid levels at the plasma and intracellular membranes

Year: 2025

Type: article

Abstract: receptors with bradykinin increased 2-AG levels at both the plasma and intracellular membranes within ≈5 and ≈15 s, respectively. By contrast, the activation of G proteins by the small peptide mastoparan and the ensuing opening of plasma membrane calcium channels increased 2-AG levels in plasma membrane within ≈1-2 s and in intracellular membranes after ≈30 s. While both these stimuli-induced increases in 2-AG production involved canonical lipases, they required distinct sources of calcium. Thus, distinct stimuli differentially increase 2-AG levels at plasma and intracellular membranes via distinct molecular mechanisms.

Source: iScience

DOI: 10.1016/j.isci.2025.113873