Maternal undernutrition exacerbates microbiota-driven growth stunting through pre- and postnatal effects
Year: 2025
Type: article
Abstract: Linear growth stunting due to undernutrition affects 20% of children under the age of 5, with far-reaching consequences, including increased susceptibility to infection and altered cognitive development. Current nutritional interventions are largely ineffective in rescuing linear growth. A significant proportion of stunting originates in utero; however, the mechanisms by which maternal undernutrition is transmitted between generations remain poorly characterized. Here, we employ a gnotobiotic murine model of intergenerational undernutrition in which offspring are exposed to distinct microbial communities both in utero and after birth. We find that maternal undernutrition exacerbates offspring growth deficits in a microbiota-dependent manner. Maternal undernutrition also alters the offspring microbiome, increasing the abundance of Enterococcus species and Escherichia coli. Cross-fostering demonstrates critical roles for the microbiota in growth during both gestation and early life. These findings emphasize the need to target both mother and child in the design of nutritional therapies for undernutrition.
Source: Cell Reports
Institution: University of Virginia
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4415613042