Work

Current status and future prospects of mesenchymal stem cell-derived exosomes therapy for premature ovarian insufficiency

Year: 2025

Type: article

Abstract: Premature ovarian insufficiency (POI) is an endocrine disorder that seriously affects the reproductive health and quality of life of women of reproductive age. At present, there is no effective treatment to restore ovarian function. In recent years, accumulating studies have demonstrated that mesenchymal stem cells-derived exosomes (MSC-EXO) can restore ovarian function and fertility in POI animals by inhibiting apoptosis of ovarian granulosa cells, inflammatory response or fibrosis, and improving vascular function. However, there are still many deficiencies in this new treatment, such as the lack of standardized production of EXO, long-term safety and efficiency issues, and low homing efficiency, which limit its clinical translation and widespread application. Therefore, further research is required to address challenges such as achieving standardized mass production and targeted delivery of EXO, as well as to fully elucidate their underlying mechanisms of action. This review comprehensively summarizes the current progress of MSC-EXO in POI treatment, covering topics including MSC-EXO extraction and identification techniques, their therapeutic mechanisms in POI, POI animal models, and the clinical application potential of MSC-EXO, aiming to provide support for advancing basic research and facilitating clinical applications in this field.

Source: Journal of Ovarian Research

DOI: 10.1186/s13048-025-01813-0

Authors: Xiao Zhang, Shaowei Wang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290