Work

Case report and narrative review of the diagnosis and treatment of Alagille syndrome in an adult pregnant patient

Year: 2025

Type: review

Abstract: Alagille syndrome is a genetic disorder with an autosomal dominant hereditary pattern. Clinical manifestations include craniofacial, ocular, cardiac, hepatic, renal, vascular, and skeletal abnormalities with varying phenotypic penetrance; therefore, treatment would be targeted to the affected organs. A successful pregnancy in this pathology is uncommon and depends on the maternal features, particularly those that involve the cardiovascular and hepatobiliary systems. The objective of the manuscript is to present the case of a 24-year-old pregnant woman with a diagnosis of Alagille syndrome, her therapeutic challenge, and associated conditions.

Source: Gynecology Obstetrics and Reproductive Medicine

DOI: 10.21613/gorm.2025.1610

Authors: Alejandro Rojas-Urrea, Daniela Arias-Mariño, Fernanda E Landines-Peña, Brumel Armando Niño-Patarroyo, Lorena García-Agudelo

Language: English

Topic: Pediatric Hepatobiliary Diseases and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415614476

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