Work

β-Branching in the biosynthesis of bongkrekic acid: a complex affair

Year: 2025

Type: article

Abstract: Bongkrekic acid biosynthesis requires a cassette of β-branching enzymes (BonF–BonI) to install two distinct β-branches. Here we confirm the roles of BonF–BonI in vitro and uncover a previously unannotated ACP D , BonN.

Source: RSC Advances

DOI: 10.1039/d5ra05400a

Authors: Megan E. M. Hiseman, Annabel P. Phillips, Ciprian Chiriac, Liam J. Smith, John Crosby, Christopher Williams, Christine L. Willis, Ashley J. Winter, Matthew P. Crump

Institution: University of Bristol

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: Directorate for Biological Sciences, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis

Awards: Structural and Mechanistic Investigations of Antibiotic Production in Bacteria, G3012223249, DTP 2224 University of Bristol, G5558554490, EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis, New tools for elucidating natural product biosynthesis in-situ at atomic resolution

OpenAlex ID: W4415617146

FWCI: 0.485

Cites: 37

Cited by: 1

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