Work

Flash Communication: Cobalt-Catalyzed Asymmetric Hydrogenation of a Fluorinated Cyclobutenoic Acid Derivative

Year: 2025

Type: article

Abstract: An enantioselective hydrogenation of a fluorinated cyclobutenoic acid derivative using both neutral cobalt(II) and cationic, bis(phosphine)-supported cobalt(I) precatalysts has been developed. With a bis(phosphine)-supported cobalt(I) precatalyst, complete conversion and >99% ee was obtained at ambient temperature, enabling a route for the preparation of an enantioenriched bis(difluoro)-substituted cyclobutane. Deuterium-labeling studies supported homolytic cleavage of dihydrogen and established the unsaturated starting material was not isomerized under catalytic hydrogenation conditions.

Source: Organometallics

DOI: 10.1021/acs.organomet.5c00366