Psychometric properties of the NIH Toolbox Cognition Battery composites in older adults at risk for Alzheimer's disease and related dementias: A systematic review
Year: 2025
Type: review
Study design: Systematic Review
Abstract: This systematic review evaluated the psychometric performance of the National Institutes of Health's Toolbox Cognition Battery (NIHTB-CB) composite scores in older adults with and without Alzheimer's disease and related dementias (ADRD). A systematic literature search was conducted using MEDLINE, Embase, PsycINFO, and CINHAL databases. The evidence quality of NIHTB-CB measurement properties was assessed using integrated Consensus-based Standards for the Selection of Health Measurement Instrument (COSMIN) methodology and the Interpretation/Use Argument framework. Fourteen studies met inclusion criteria for this review of the NIHTB-CB. Evidence supporting the scoring, generalization, and extrapolation inferences of the Total, Crystallized, and Fluid composite scores in older adults ranged from developing through exemplary ratings. Findings indicate additional research is warranted on the NIHTB-CB in older adult and ADRD populations. The present study highlights the importance of continued use and research of the NIHTB-CB in diverse, older populations who are at risk for ADRD. HIGHLIGHTS: Limited research focuses on the National Institutes of Health's Toolbox Cognition Battery (NIHTB-CB) composites in older adults. The general psychometric robustness of the NIHTB-CB has been es. The Crystallized composite shows proficient psychometric evidence. The psychometric evidence of Fluid composite is developing due to limited data.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.70673
Institutions: Washington State University Spokane, Washington State University Tri-Cities, Fred Hutch Cancer Center, University of Washington, University of California, San Francisco, Northwestern University, University of California San Diego, Washington State University, Boston University, California State University, Fullerton
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Funder: National Institute on Aging
Awards: Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart Study, Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart Study, University of Washington Alzheimer's Disease Research Center
OpenAlex ID: W4415619597