Work

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

Year: 2025

Type: article

Source: Molecular Cell

DOI: 10.1016/j.molcel.2025.10.002

Authors: Mushtaq A. Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel J. McGrail, Nidhi Sahni, Niklas B. Thompson, Peter A. Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben-Sahra

Institutions: Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Cleveland Clinic, The University of Texas MD Anderson Cancer Center, University of Chicago Medicine Comprehensive Cancer Center, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, Cancer Prevention and Research Institute of Texas, LAM Foundation, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences

Awards: National Resource for Translational and Developmental Proteomics, G2930142762, G3698915505, G4095781974, Control of RNA methylation by growth signals through the mTORC1 pathway, G4782957160, Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometer, G717878948, G7986825734, The Robert H. Lurie Comprehensive Cancer Center

OpenAlex ID: W4415619677

FWCI: 4.077

Cites: 52

Cited by: 16

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