Work

Direct Synthesis of α-Amino Ketones via Photochemical Nickel-Catalyzed Acyl–Aryl Cross-Coupling

Year: 2025

Type: article

Abstract: We report a direct method for synthesizing α-amino arylketones via photochemical nickel-catalyzed acyl-aryl cross-coupling of α-amino acid-derived aldehydes with aryl bromides. The reaction proceeds efficiently under mild conditions, particularly with electron-deficient aryl bromides, and provides mechanistic insights into the competition between ketone formation and decarbonylation pathways. The protocol further enables the straightforward preparation of cathinone derivatives, highlighting its synthetic versatility and potential in medicinal and forensic chemistry.

Source: ACS Omega

DOI: 10.1021/acsomega.5c08932

Authors: Mariana dos S. Dupim, Gustavo dos S. Martins, Thais G. Silva, Fernanda G. Finelli

Institution: Universidade Federal do Rio de Janeiro

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro