Work

Magnetic reduced graphene oxide aerogel decorated silver nanoparticles towards efficient recognition of doxorubicin in patients’ blood plasma

Year: 2025

Type: article

Abstract: Doxorubicin (DOX), a potent anticancer drug, requires sensitive and precise detection due to its narrow therapeutic window. In this study, a novel electrochemical sensor was developed by electrodepositing silver nanoprisms (AgNPrs), Fe 3 O 4 nanoparticles, and reduced graphene oxide aerogel (rGOA) on a glassy carbon electrode (GCE). The cyclic voltammetry technique was utilized for electrodeposition of Fe 3 O 4 @rGOA/AgNPrs nanocomposite within a potential range of − 1.0 to + 1.0 V. The Fe 3 O 4 @rGOA/AgNPrs–modified GCE probe was optimized for the detection and quantification of DOX in human plasma samples. At an optimized pH of 6, DOX exhibited distinct redox behavior on the modified electrode. Differential pulse voltammetry was employed for the quantification of DOX and showed a wide linear dynamic range (0.075 to 5.0 µg/mL) with a low limit of quantification (LLOQ) of 0.075 µg/mL and limit of detection (LOD) of 0.028 µg/mL in blood plasma. The developed sensor demonstrated excellent sensitivity, selectivity, and reproducibility, enabling direct quantification of DOX in plasma samples. These findings underscore the potential of the proposed sensor as a reliable, efficient, and cost-effective platform for therapeutic drug monitoring and clinical diagnostics.

Source: Scientific Reports

DOI: 10.1038/s41598-025-21459-8

Authors: Hadi Gheybalizadeh, Mina Goli, Mohammad Hasanzadeh, Yosra Vaez-Gharamaleki, Abolghasem Jouyban, Jafar Soleymani

Institution: Tabriz University of Medical Sciences

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690