Year: 2025
Type: article
Abstract: A Pd-catalyzed synthesis of phenols in 10% aqueous poly-(ethylene glycol)-2000 (PEG) under an air atmosphere is reported. The reaction proceeds with NaOH as opposed to other BippyPhos/Pd systems in organic solvents that rely on more expensive and reactive CsOH. The reported method converts aryl chlorides, bromides, and iodides with a variety of functional groups at 90 °C to the corresponding phenols in moderate to excellent yields. Due to the aerobic atmosphere, these conditions also oxidize benzyl alcohol substituents to the corresponding aldehyde.
Source: ACS Omega
Authors: Gwendolyn A. Jones, Mariam Beshara, Jacob E. Levin, Alana R. Garcevic, Diana G. Rosiles-Dueñas, Yousif A. Saleh, Erica E. Schultz
Institution: Lake Forest College
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Funder: Lake Forest College
OpenAlex ID: W4415623165