Work

The rational design of coordination-driven supramolecular artificial enzymes: From catalysis to biomedicine

Year: 2025

Type: article

Abstract: Self-assembled coordination architectures are emerging as powerful platforms for creating artificial enzymes that emulate the structural and functional complexity of natural biocatalysts. By combining well-defined cavities, tunable host-guest interactions, and catalytic control within confined nanoscale spaces, these systems offer unique opportunities for advancing sustainable catalysis, molecular recognition, and biomedical innovation. In this perspective, we highlight recent advances in the design and function of coordination-driven artificial enzymes, focusing on how metal-organic architectures (MOAs) can be engineered to stabilize reactive intermediates, direct substrate selectivity, and respond to external stimuli. We outline the principles behind these supramolecular systems and explore their growing potential in both industrial and therapeutic contexts.

Source: Chem

DOI: 10.1016/j.chempr.2025.102784

Authors: Agnieszka Bajer, Venkateswarulu Mangili, Artur R. Stefankiewicz

Institution: Adam Mickiewicz University in Poznań

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $9,350

Funders: Narodowe Centrum Nauki, Horizon 2020 Framework Programme, H2020 Marie Skłodowska-Curie Actions