Work

RBM15 in diseases: Molecular mechanisms and clinical opportunities from RNA m6A methylation

Year: 2025

Type: article

Abstract: RNA m 6 A methylation is the most common type of RNA modification, and RBM15 regulates various cellular processes by writing m 6 A methylation on RNA. m 6 A methylation mediated by RBM15 significantly affects RNA stability and translational efficiency, thereby regulating gene expression. In-depth studies have revealed that RBM15 affects the progression of various diseases by regulating the expression of multiple genes, and its m 6 A methylation modification process is also considered to be an effective therapeutic target. In this paper, we review the latest research progress on the regulation of m 6 A methylation modification of RBM15, its molecular regulation in various diseases, such as cancer and metabolic diseases, and the potential therapeutic drugs derived from it, with a view to providing therapeutic strategies for the subsequent research on RBM15 and gene therapy targeting RBM15.

Source: Genes & Diseases

DOI: 10.1016/j.gendis.2025.101901