Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Few population-based studies on nasopharyngeal carcinoma (NPC) prognosis exist. Such real-world data with complete follow-up are needed to enable accurate estimation of survival probabilities and monitor progress in early detection and treatment. METHODS: In a population-based study of 2529 patients with incident NPC in southern China diagnosed in 2010-2013, we developed a passive-active-passive follow-up strategy involving data linkage and direct contact to track patients' vital status, cause of death, and migration through December 31, 2018. We calculated 5-year survival probabilities by the Kaplan-Meier method, and estimated avoidable deaths comparing hypothetical scenarios and real-world observations. RESULTS: Early-stage (I-II) patients accounted for 11·5%, and 21·1% were treated in medical-university-affiliated or province-level hospitals. With a mean follow-up time of 5·5 years after diagnosis (98.3% complete), 5-year overall and NPC-specific survival probabilities were 70·1% and 74·5%. The 5-year overall survival probabilities for stage I, II, III, IVa, IVb, and IVc were 91·3%, 87·8%, 79·8%, 63·9%, 57·7%, and 34·4%, respectively. Survival of non-metastatic (I-IVb) population-based patients diagnosed in 2010-2013 was comparable to that of a hospital-based southern Chinese NPC cohort diagnosed in 1997-2007. Based on observed data, if all patients were diagnosed at stages I-II, then total avoidable deaths within 5 years after diagnosis would be 156 per 1000 patients. CONCLUSIONS: Real-world population-based NPC survival lags behind that of large hospital-based cohorts, but earlier diagnosis has the potential to substantially reduce mortality from NPC. Our results highlight the importance of improving the accessibility of health resources and promoting early detection of NPC.
Source: British Journal of Cancer
Institutions: Army Medical University, Karolinska Institutet, Southwest Hospital, Fujian Medical University, Shanxi Medical University, University of California, San Francisco, Guangxi Medical University, First Affiliated Hospital of GuangXi Medical University, Wuzhou Red Cross Hospital, Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, University of Oslo
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: Epidemiological studies on the role of microbe-human interaction in cancer development, G2417203958, G3075301304, G3860280835, Sino-Swedish collaborative etiologic and epidemiological studies on cancer, Sino-Swedish collaborative epidemiological studies to understand the enigmatic high incidence of nasopharyngeal carcinoma in southern China, 高发区基于EB病毒抗体联合循环肿瘤细胞筛查早期鼻咽癌体系的建立以及流行病学研究, Gene-environment EBV Interactions in the Etiology of Nasopharyngeal Carcinoma (NP, G5726169036
OpenAlex ID: W4415642495