Work

Synthesis of 4‐Indolyl‐5‐Aminopyrazoles via Catalytic Arylation of 5‐Aminopyrazoles With 2‐Indolylmethanols

Year: 2025

Type: article

Abstract: A Brønsted acid-catalyzed arylation of 5-aminopyrazoles with 2-indolylmethanols was established, which effectively afforded 4-indolyl-5-aminopyrazoles in high yields (up to 98%). Biological evaluation demonstrates the promising application of these 4-indolyl-5-aminopyrazoles in medicinal chemistry. This reaction not only provides a novel class of biologically active 4-aryl-5-aminopyrazoles but also offers an efficient strategy for synthesizing 4-(five-membered heteroaryl)-5-aminopyrazoles.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500861

Authors: Yu‐Yu Chen, Tian‐Ya Liu, Jia Xue, Cheng‐Ye Xu, Yu‐Chen Zhang, Feng Shi

Institutions: Jiangsu Normal University, Xuzhou Medical College, Changzhou University

Language: English

Topic: Synthesis of Indole Derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Program for Jiangsu Excellent Scientific and Technological Innovation Team, Basic Research Program of Jiangsu Province

Awards: G2772603393, G4481430925, G7864749644