Association between triglyceride glucose body mass index and the prognosis of patients with atrial fibrillation complicated with acute coronary syndrome: a prospective study
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The triglyceride-glucose body mass index (TyG-BMI) is a reliable marker of insulin resistance and has been linked to cardiovascular outcomes. However, data on the relationship between TyG-BMI and prognosis in patients with atrial fibrillation (AF) complicated by acute coronary syndrome (ACS) are limited. This study aimed to evaluate the association between baseline TyG-BMI and prognosis in AF-ACS patients. METHODS: We conducted a single-center prospective analysis of 832 AF-ACS patients hospitalized at Fuwai Hospital from January 2017 to December 2019. The primary outcome was the incidence of major adverse cardio-cerebrovascular events (MACCEs) during the 1-year follow-up. Kaplan-Meier curves compared MACCE risk across four TyG-BMI quartiles. Cox proportional hazards regression and restricted cubic spline (RCS) analyses assessed the relationship between TyG-BMI and patient outcomes. RESULTS: The mean age of participants was 68.15 ± 9.59 years, with 569 (68.39%) being male. Kaplan-Meier analysis showed significant differences in 1-year MACCE risk between the four groups. Cox regression revealed that patients in the lowest TyG-BMI quartile had a significantly higher 1-year MACCE risk. RCS analysis indicated a linear increase in MACCE risk with decreasing TyG-BMI. CONCLUSION: TyG-BMI is closely associated with the prognosis of AF-ACS patients. Lower TyG-BMI is significantly linked to a higher risk of MACCEs in this population.
Source: BMC Cardiovascular Disorders
Authors: Yijing Xin, Yimeng Wang, Yuyuan Shu, Hanyang Liang, Yanmin Yang, Ping Qing
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W4415648246