Work

Harnessing chimeric antigen receptor (CAR)-T cells as a potential treatment for Alzheimer’s disease

Year: 2023

Type: article

Abstract: Alzheimer's disease (AD) significantly burdens global healthcare systems given limited treatment options to delay or stop disease progression. Chimeric antigen receptor (CAR) T cell therapy, an immunotherapeutic approach that has produced remarkably effective responses in cancer, offers a potential avenue for the treatment of AD. Here, we discuss three significant challenges of adapting CAR-T cell therapy for AD: (i) identifying a suitable antigen target; (ii) limited permeability of the blood-brain barrier; and (iii) long-term persistence and durability of manufactured CAR-T cell products. Potential strategies to overcome these hurdles provide an attractive opportunity to revolutionize the treatment for AD and potentially other neurodegenerative disorders.

Source: Cell and Gene Therapy Insights

DOI: 10.18609/cgti.2023.132

Authors: Lauren Sarko, Krishanu Saha

Institution: University of Wisconsin–Madison

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Wisconsin Alumni Research Foundation, National Institutes of Health, National Institute of General Medical Sciences