Work

Effects of two structurally diverse positive allosteric modulators on signaling bias at the μ-opioid receptor

Year: 2025

Type: article

Source: Molecular Pharmacology

DOI: 10.1016/j.molpha.2025.100079

Authors: Mengchu Li, Kelsey E. Kochan, M. Alexander Stanczyk, Hannah C. Stewart, Joshua L. West, Andrew D. White, Zara Y. Weinberg, Manojkumar A. Puthenveedu, John R. Traynor

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Michigan, National Institutes of Health, National Institute on Drug Abuse, National Institute of General Medical Sciences

Awards: Allosteric Modulation of the Mu-Opioid Receptor, Mechanisms Ensuring Sequence-Dependent GPCR Recycling, Development of negative allosteric modulators of the mu-opioid receptor for the management of opioid use disorder, Interdepartmental Training in Pharmacological Sciences, Regulated trafficking and compartmentalized signaling of opioid receptors

OpenAlex ID: W4415648793

FWCI: 0.721

Cites: 49

Cited by: 3

Related to: 10