Work

Challenges in diagnosing sticky platelet syndrome using light transmission aggregometry: a scoping review

Year: 2025

Type: article

Abstract: Sticky Platelet Syndrome (SPS) is an inherited platelet hyperreactivity disorder associated with recurrent arterial and venous thrombosis. However, its diagnosis remains controversial due to substantial variability in light transmission aggregometry (LTA), the reference method. To map current diagnostic practices, we conducted a scoping review following PRISMA-ScR and JBI methodology, systematically searching Scopus, MEDLINE, Embase, and Google Scholar. We included 27 studies that collectively demonstrate considerable heterogeneity in patient preparation, sample handling, agonist usage, and data interpretation. These differences span pre-analytical and analytical variables such as washout periods, citrate concentration, centrifugation conditions, and threshold derivation methods. While detailed synthesis is ongoing, our preliminary observations highlight critical inconsistencies that may limit comparability across laboratories. This review underscores the need for standardized diagnostic approaches. Establishing harmonized protocols and validating them across centers could improve diagnostic accuracy and support better platelet function testing in SPS and related disorders.

Source: Platelets

DOI: 10.1080/09537104.2025.2560380

Authors: Yupeng Wu, Floris van Dellen, Hugo ten Cate, Yvonne Henskens, Kristien Winckers

Institutions: Maastricht University Medical Centre, Maastricht University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,970