Work

Research progress on the mutual regulatory mechanism of circadian clock genes and autophagy

Year: 2025

Type: article

Abstract: Recent studies have highlighted the intricate relationship between the circadian rhythm, a natural biological process responsive to light and darkness, and autophagy, a mechanism crucial for maintaining cellular homeostasis. Circadian clock genes, which are pivotal in regulating our internal body clock, appear to be closely intertwined with autophagy. These genes can directly influence the expression of autophagy-related genes or modulate signalling pathways that govern autophagic processes. Conversely, autophagy also controls the expression and activity of circadian clock genes. Investigating these interactions will help elucidate how autophagy and circadian rhythms maintain cellular equilibrium and regulate physiological functions. Moreover, such studies help reveal disease mechanisms and develop potential therapeutic strategies.

Source: Frontiers in Cell and Developmental Biology

DOI: 10.3389/fcell.2025.1696985

Authors: Yueqi Ma, Ran Yu, Xueqing Zheng, Jiahui Rao, Gaiping Shi, Yumei Ding

Institutions: Wuhan Union Hospital, Huazhong University of Science and Technology

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,801

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities