Work

Efficient Synthesis of Amides through Thioacids Reactions with In Situ Generated Formamidine

Year: 2025

Type: article

Abstract: A formamidine intermediate generated in situ was used as the nitrogen source in a reaction with thioacids to obtain amides. The synthetic protocol described in this paper can be used in the generation of various primary, secondary, and tertiary amides with organic thioacids used as substrates under the optimized conditions. Notably, this protocol uses readily available materials, is nearly solvent-free, supports gram-scale synthesis, and yields structurally diverse amide products with favorable efficiency.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01644

Authors: Chin-Ling Kuo, Yan-Jie Chen, Hsiang-Jou Chen, Ching-Ching Yu, Chien-Fu Liang

Institutions: National Chung Hsing University, National Tsing Hua University, Institute of Biological Chemistry, Academia Sinica, Academia Sinica

Language: English

Topic: Synthesis and Reactivity of Sulfur-Containing Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Ministry of Education, India, National Chung-Hsing University, National Science and Technology Council