Year: 2025
Type: article
Abstract: Sarcopenia and atherosclerosis are prevalent age-related conditions increasingly recognized as interconnected through shared immune-mediated pathways. This review elucidates how "inflammaging" driven by dysregulated immune responses. Key age-related mechanisms include macrophage polarization imbalance, T/B cell dysregulation, and activation of pro-inflammatory signaling pathways. These processes promote oxidative stress, insulin resistance, creating a vicious cycle that exacerbates muscle and vascular decline. Emerging therapeutic strategies offering potential for dual-benefit interventions. Understanding these immune interactions provides a foundation for integrated approaches to mitigate sarcopenia and atherosclerosis in aging.
Source: Immunity & Ageing
Authors: Mei Yu, Rujia Zhao, Lichao Ge, Tong Yu, Hangyan Shen, Chengyi Dai, Haihua Wang
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
OpenAlex ID: W4415658676