Summary of the Best Evidence on Skin-Mucosal Care in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Year: 2025
Type: article
Study design: Systematic Review
Abstract: OBJECTIVE: The aim of this study was to retrieve, evaluate, and summarize the best available evidence on skin-mucosal care for patients with Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN). DATA SOURCES: The data were gathered from national and international databases and reputable websites. A top-down approach was applied following the 6S Evidence Search Model, with a search time frame from the time of database construction to December 25, 2023. Multiple sources, including clinical decisions, guidelines, and expert consensus, were reviewed. STUDY SELECTION: Studies that addressed skin-mucosal care in patients with SJS/TEN were eligible for inclusion. The literature was rigorously screened to ensure its relevance and methodological quality. A total of 11 documents were included in this review, which consisted of 1 clinical decision, 5 clinical practice guidelines, and 5 expert consensus documents. DATA EXTRACTION: Two researchers independently assessed the quality of the included studies, extracted evidence, and summarized the findings. A total of 34 pieces of evidence spanning 6 dimensions of skin-mucosal care were identified and categorized. DATA SYNTHESIS: The extracted evidence was synthesized and summarized to provide actionable insights for clinical practice. The evidence focused on wound care, infection prevention, pain management, hydration, and specific recommendations for skin-mucosal care tailored to the unique needs of patients with SJS/TEN. CONCLUSIONS: This article offers a comprehensive evidence-based basis for effective skin-mucosal care to SJS/TEN patients. These best practices can improve patient outcomes and contribute to better clinical management.
Source: Advances in Skin & Wound Care
Authors: Yanping Lei, Zonghuang Ding, Chunrong Yuan, Ming Liu, Qiuting Dai, Jun Wei
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415658720