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Asymptomatic Influenza A(H5N1) Infections and Sustained Surveillance—Sustaining Surveillance Beyond the Crisis

Year: 2025

Type: article

Abstract: Dawood and colleagues 1 provide an important insight into influenza A(H5N1) infections and the surveillance tools needed for pandemic preparedness.Through rigorous review of international literature and careful molecular and serologic confirmation in 16 cases outside of the US, the authors document that influenza A(H5N1) infections among humans do not always present with severe illness, that asymptomatic infections occur, and in some settings, there is probable person-to-person transmission.This finding challenges the traditional perception that influenza A(H5N1) infection among humans is almost invariably symptomatic and severe.However, the operational rollout of surveillance measures revealed vulnerabilities.Asymptomatic testing of exposed workers was not initiated quickly, early human surveillance was limited in scope, +

Source: JAMA Network Open

DOI: 10.1001/jamanetworkopen.2025.40255

Authors: Rick A. Bright, Nicole Lurie

Institutions: Harvard University, Coalition for Epidemic Preparedness Innovations

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000