Work

Photocatalytic synthesis of CF3-containing β -amino alcohols via covalent metal–organic frameworks

Year: 2025

Type: article

Abstract: ABSTRACT The construction of CF3-containing β-amino alcohols represents a promising approach for drug discovery due to their enhanced metabolic stability and tunable pharmacological properties. However, the development of non-noble metal heterogeneous photocatalysts for the efficient one-step synthesis of trifluoromethyl (CF3)-containing β-amino alcohol motifs under mild conditions poses significant challenges. In this work, we successfully synthesized two photoactive covalent metal–organic frameworks capable of photocatalysing the one-step conversion of allylamines into CF3-containing β-amino alcohols via trifluoromethylation and photooxidation. Notably, the catalytic reaction can be performed under continuous-flow conditions, reducing the reaction time from 12 h to 50 min while achieving a product yield of 6.2 g of CF3-containing β-amino alcohol. Additionally, under a CO2 atmosphere, CF3-containing oxazolidinones can be efficiently obtained through the oxytrifluoromethylation of alkenes. Both catalytic reactions demonstrate high yields under natural sunlight illumination, further highlighting the practicality and sustainability of this approach.

Source: National Science Review

DOI: 10.1093/nsr/nwaf463