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Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models

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Year: 2025
Type: article
Source: Science Translational Medicine
DOI: 10.1126/scitranslmed.adk0627
Authors: Xin Du, Pei K. Goh, Chenkai Ma, Eamon Coughlan, Spencer Greatorex, Laura H. Porter, Brendan Russ, Katherine D. Cummins, Kevin Sek, Clare Y. Slaney, Andrew M. Scott, Jane Oliaro, Paul J. Neeson, Gail P. Risbridger, Renea A. Taylor, Joseph A. Trapani, Stephen J. Turner, Phillip K. Darcy, Florian Wiede, Tony Tiganis
Institutions: Monash University, Monash Institute of Medical Research, Commonwealth Scientific and Industrial Research Organisation, CSIRO Health and Biosecurity, The University of Melbourne, Peter MacCallum Cancer Centre, La Trobe University, Olivia Newton-John Cancer Research Institute
Language: English

Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
SDG: Good health and well-being

Open Access status: closed
OpenAlex ID: W4415671650
FWCI: 2.964
Cites: 94
Cited by: 8
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