Work

Engineering Cancer with Next-Generation Genome Editing Tools

Year: 2025

Type: review

Abstract: Genome editing technologies have given us the ability to manipulate a genome with unprecedented accuracy. In cancer research, these technologies have enabled precise disease modeling in cells and in vivo and facilitated systematic efforts to identify cancer drivers and dependencies. This review examines the current landscape of genome editing technologies, with an emphasis on next-generation methods to engineer complex nucleotide and chromosomal alterations. We highlight key examples that illustrate how these technologies have provided fundamental insights into this disease, and we discuss new approaches that integrate genome editing with multiomic methods. Finally, we discuss recent efforts to translate these technologies into the clinic.

Source: Annual Review of Cancer Biology

DOI: 10.1146/annurev-cancerbio-070824-123431

Authors: Jonathan F. Roth, Evelyn Chen, Hannah Cevasco, Francisco J. Sánchez-Rivera

Institutions: Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415673810

FWCI:

Cites: 219

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