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Decoding the Unexpected: How Cell-Free DNA Sequencing Unveiled an Elusive Tularemia Case

Year: 2025

Type: article

Abstract: , leading to diagnosis of typhoidal tularemia. This case demonstrated mcfDNA's utility for diagnosing rare zoonotic infections that would likely remain undiagnosed using conventional methods. The authors propose molecular testing should be considered for updated tularemia case definitions for public health surveillance. Clinicians should maintain suspicion for zoonotic diseases in patients with undifferentiated fever in California.

Source: The Permanente Journal

DOI: 10.7812/tpp/25.070

Authors: Jack R Watson, Rehan R Syed, Victor Manuel Salazar, George Dahdouh, Jacqueline Bursalyan, Anya English, Hector Ponce-Sanchez, Fernanda Urrutia, Fiona Chan, Mokshitaa Dhamotharan, Natalie Gonzalez, Bethlehem Messele, Saahil Mohta, Jyoti Sah

Institutions: Kaiser Permanente, Kaiser Permanente San Rafael Medical Center, Santa Clara University, University of California, Santa Cruz, University of California, Berkeley, San Jose State University

Language: English

Topic: Bacillus and Francisella bacterial research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415675485

FWCI:

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