Work

Rotational Thromboelastometry (ROTEM)-Assisted Anaesthetic Management of a Parturient With Paroxysmal Nocturnal Haemoglobinuria and Aplastic Anaemia for Caesarean Section: A Case Report

Year: 2025

Type: article

Abstract: Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired, clonal haematopoietic disorder. It is life-threatening and is characterized by intravascular haemolytic anaemia, large vessel thrombosis and bone marrow failure. Aplastic anaemia (AA) and PNH are intimately linked; however, concurrent treatment of PNH and AA is uncommon. Pregnancies in patients with PNH are rare and associated with increased maternal and fetal morbidity and mortality. Nevertheless, with the advent of eculizumab, a monoclonal antibody used to treat PNH, pregnancy outcomes have become more favourable. The obstetric and anaesthetic management of affected patients poses significant challenges, making multidisciplinary involvement essential. We report the successful management of a parturient with PNH and severe AA who underwent a scheduled caesarean section.

Source: Cureus

DOI: 10.7759/cureus.95701

Authors: Despoina Fani Papadaki, Emmanouil Stamatakis, Giolanda Varvarousi, Dimitrios Valsamidis

Institutions: Hellenic Red Cross, Red Cross Hospital, Alexandra Hospital

Language: English

Topic: Blood transfusion and management

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415677684