Effects of Paraprobiotic Limosilactobacillus fermentum HDB1098 on Hangover Improvement in Humans: A Randomized Double-Blind Placebo-Controlled Crossover Clinical Trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Hangover refers to various mental and physical side effects following alcohol consumption.This study investigated the efficacy of paraprobiotic Limosilactobacillus fermentum HDB1098 (MB-LFH1098, Pharmavio ALC) on improving hangover symptoms and was designed as a randomized double-blind crossover placebo-controlled clinical trial conducted with 28 participants.Participants consumed 42.8% whiskey with equivalent to 90 g of alcohol and serum alcohol and acetaldehyde levels were measured at 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption.Both serum alcohol (p < 0.01) and acetaldehyde (p < 0.05) levels over time, AUC, C max , and T max for serum acetaldehyde level were significantly lower (p < 0.05) in the HDB1098 group compared to the placebo group.Furthermore, the total scores of AHS and AHSS were significantly lower (p < 0.0001) in the HDB1098 group than the placebo group, with improvement of several indicators in each questionnaire.These findings indicate that HDB1098 administration can effectively contribute to relief of hangover symptoms.
Authors: Yoo Kyung Kim, Hyeon Jeong Kim, Min-Kyu Yun, Seunghun Lee, Dae-Jung Kang
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: bronze
Funder: Kyung Hee University
OpenAlex ID: W4415680608
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