Work

Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis

Year: 2025

Type: article

Abstract: Breast cancer is a leading cause of cancer-related mortality worldwide, with drug resistance remaining a major therapeutic challenge. We integrated multi-omics data-including GWAS, eQTL, and pQTL-with Mendelian randomization to identify genes associated with breast cancer risk and therapy response. Our analyses revealed CTSF and GSTM3 as key candidates, showing consistent associations at both RNA and protein levels. Functional studies indicated that CTSF expression correlates with taxane resistance but cyclophosphamide sensitivity, while GSTM3 influences response across multiple regimens. Enrichment analyses suggest roles in immune and hormone signaling pathways. These findings highlight CTSF and GSTM3 as potential biomarkers and therapeutic targets for overcoming chemoresistance in breast cancer.

Source: iScience

DOI: 10.1016/j.isci.2025.113908

Authors: Rui Liu, Ying Yao, Zhihua Lv, Jingtao Huang

Institutions: Renmin Hospital of Wuhan University, Jiangnan University

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240