Antibacterial and Biocompatible Penicillin–Streptomycin Loaded Bacterial Cellulose (BC) Hydrogels for Wound Healing
Year: 2025
Type: article
Abstract: Bacterial cellulose (BC) hydrogel is a promising skin wound healing biomaterial due to its unique properties, including a moist environment that facilitates tissue healing. To enhance its antimicrobial efficacy, BC dressings were loaded with penicillin and streptomycin. FT-IR analysis confirmed successful drug binding, while SEM revealed a nanofibrous and porous hydrogel structure. In vitro studies using 3T3 mouse fibroblasts demonstrated biocompatibility, and scratch wound assays achieved complete closure across all tested concentrations. Antibacterial activity, assessed via agar diffusion against Pseudomonas aeruginosa and Staphylococcus aureus, showed a concentration-dependent increase in inhibition zones, highlighting the potential of BC-Pen/Strep hydrogels as effective antimicrobial wound dressings.
Source: Gels
DOI: 10.3390/gels11110851
Institution: University of Salento
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,534
Awards: G1888088267, G1888792705
OpenAlex ID: W4415683388