Alterations of Raman Profiles of Cystic Echinococcosis Serum After Treated With ABZ by SERS
Year: 2025
Type: article
Abstract: ABSTRACT Cystic echinococcosis (CE) is often treated with albendazole (ABZ). Surface‐enhanced Raman scattering (SERS) has high sensitivity and specificity, as well as low sample consumption, but its ability to identify changes in serum compounds post‐ABZ treatment is unclear. This study used SERS to characterize the Raman profiles of serum from 7 normal, 9 CE‐model, and 10 ABZ‐treated mice, analyzing profile differences. Tentative peak assignments revealed ABZ‐induced biomolecular changes in protein structure (1000 cm −1 ), uric acid (1130 cm −1 ), amide III (1203 cm −1 ), phospholipids, and amide I (1656 cm −1 ). The top 10 principal components (PCs) accounted for 90% of the variance (PC1: 48.9%). Principal components analysis (PCA) loadings suggested these substances as markers of ABZ treatment. The results show that SERS combined with PCA is a rapid and effective method to observe serum changes in Echinococcus granulosus ‐infected subjects.
Source: Journal of Biophotonics
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4415683623