Year: 2025
Type: article
Abstract: Introduction Neural activity can be described in terms of probability distributions that are continuously evolving in time. Characterizing how these distributions are reshaped as they pass between cortical regions is key to understanding how information is organized in the brain. Methods We developed a mathematical framework that represents these transformations as information-theoretic gradient flows — dynamical trajectories that follow the steepest ascent of entropy and expectation. The relative strengths of these two functionals provide interpretable measures of how neural probability distributions change as they propagate within neural systems. Following construct validation in silico , we applied the framework to publicly available continuous ΔF/F two-photon calcium recordings from the mouse visual cortex. Results The analysis revealed consistent bi-directional transformations between the rostrolateral area and the primary visual cortex across all five mice. These findings demonstrate that the relative contributions of entropy and expectation can be disambiguated and used to describe information flow within cortical networks. Discussion We introduce a framework for decomposing neural signal transformations into interpretable information-theoretic components. Beyond the mouse visual cortex, the method can be applied to diverse neuroimaging modalities and scales, thereby providing a generalizable approach for quantifying how information geometry shapes cortical communication.
Source: Frontiers in Neuroinformatics
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415685506