Work

Advancing Rigor in Preclinical Energy Expenditure Analysis: Highlights From a New Consensus Guide

Year: 2025

Type: article

Abstract: Recent advances in indirect calorimetry have expanded the capacity to characterize energy metabolism in rodent models. However, the lack of standardized analytical and reporting practices continues to impair between-study comparability and reproducibility. A recently published consensus guide addresses these limitations by providing methodological and statistical recommendations for preclinical energy expenditure research. This Perspective summarizes the main elements of the guide and highlights their relevance for enhancing analytical rigor, data harmonization, and integration with emerging computational frameworks.

Source: Obesity

DOI: 10.1002/oby.70094

Authors: Jose E. Galgani, Edward L. Melanson

Institutions: Pennington Biomedical Research Center, Louisiana State University, Pontificia Universidad Católica de Chile, University of Colorado Anschutz

Language: English

Topic: thermodynamics and calorimetric analyses

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Agencia Nacional de Investigación y Desarrollo, Comisión Nacional de Investigación Científica y Tecnológica

Award: METABOLIC FLEXIBILITY EATING BEHAVIOR AND ADIPOSE TISSUE EXPANDABILITY ROLE OF THIS TRIAD IN THE PROPENSITY TO HUMAN OBESITY