Year: 2025
Type: article
Study design: Observational Study
Abstract: Plain Language Summary Summary: Impact of sepsis on human T-cell function and outcome was assessed. In sepsis survivors, IFNγ-production in response to T-cell stimulation remains intact, while sepsis non-survivors display exaggerated IFNγ responses to TCR-independent stimuli. Plain Language SummaryThis study explored how sepsis affects T-cell function and patient outcomes. Researchers found that sepsis survivors maintain normal IFNγ production when their T-cells are stimulated, indicating intact immune function. However, those who did not survive sepsis showed excessive IFNγ responses to stimuli that do not involve T-cell receptor (TCR) activation, suggesting a dysregulated immune response. These findings highlight differences in immune function between sepsis survivors and non-survivors, which could inform future treatments and interventions for sepsis patients. Text is machine generated and may contain inaccuracies. FAQ
Source: Shock
Authors: Charles C. Caldwell, Robert Maile, Monty B. Mazer, Patrick W. McGonagill, Christian B. Bergmann, Robert W. Gould, Mahil Rao, Miguel Hernández-Ríos, Ricardo F. Ungaro, Tyler J. Loftus, Philip A. Efron, Kenneth E. Remy, Scott C. Brakenridge, Vladimir P. Badovinac, Thomas S. Griffith, Richard S. Hotchkiss, Lyle L. Moldawer
Institutions: University of Cincinnati, UF Health Shands Hospital, University of Florida Health, University of Florida, Case Western Reserve University, University of Iowa, University Hospital Ulm, University of Minnesota, University of Washington, Harborview Medical Center, Minneapolis VA Health Care System, Washington University in St. Louis
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1726524171, G24155855, G2602507602, G3611247453, Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses state, G4757066647, G4795747401, G5723158081, G6209256292, G728908076, Stratifying Patient Immune Endotypes in Sepsis (SPIES Study), G9000107926, G9000111293, G9000120841, Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology, Enhancing Innate and Adaptive Immunity to Improve Sepsis Survival, Pathological Myeloid Activation After Sepsis and Trauma, Aligning Patient Acuity with Resource Intensity after Major Surgery, Immunological Endotyping of Chronic Critical Illness after Severe Trauma or Sepsis, CD4 T cell dysfunction and reprogramming during sepsis
OpenAlex ID: W4415707963