Work

Remote, self‐administered, smartphone cognitive testing in a registry‐based cohort: Feasibility, reliability, and validity findings

Year: 2026

Type: article

Study design: Observational Study

Abstract: BACKGROUND: Remote, smartphone-based cognitive testing may improve access to cognitive assessments for Alzheimer's disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone-based cognitive tests in a registry-based cohort. METHODS: Adults without a record of cognitive impairment (N = 1815; ages 18-92) were recruited from the University of California, San Francisco (UCSF) Brain Health Registry to complete three unsupervised smartphone cognitive testing sessions within 2 weeks. Reliability was assessed with correlations between sessions. Linear regression models tested associations of smartphone tasks with demographics, self- and informant-rated cognitive concerns, and web-based cognitive testing (Cogstate Brief Battery). RESULTS: Adherence was high (82.2%) and usability favorable. Test-retest reliability was moderate to strong (ρ's = 0.61-0.85, all p's < 0.001). Lower smartphone scores were associated with older age, lower education, cognitive concerns, and worse Cogstate performance. DISCUSSION: Findings support the feasibility, reliability, and validity of remote digital assessments in adults without a record of cognitive impairment.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.71580

Authors: Sreya Dhanam, Mark Sanderson‐Cimino, Jack Carson Taylor, Emily W. Paolillo, Ray Fregly, Winnie Kwang, Paul Maruff, Amy Wise, Hilary W. Heuer, Leah K. Forsberg, Joel H. Kramer, Bradley F. Boeve, Howard J. Rosen, R. Scott Mackin, Michael W. Weiner, Rachel L. Nosheny, Adam L. Boxer, Adam M. Staffaroni, and the Brain Health Registry

Institutions: University of California, San Francisco, UCSF Edward and Pearl Fein Memory and Aging Center, The University of Melbourne, Florey Institute of Neuroscience and Mental Health, Mayo Clinic, San Francisco VA Medical Center, University of California San Francisco Medical Center

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,200

Funders: University of California, Rainwater Charitable Foundation, National Institutes of Health, University of California, San Francisco, National Institute on Aging

Awards: Biomarker Evaluation in Young Onset Dementia from Diverse Populations (BEYONDD), The Alzheimer's Disease Tau Platform Clinical Trial, The Brain Health Registry for facilitating interdisciplinary aging research, Validating remote digital assessments for familial frontotemporal dementia, Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP, The Four Repeat Tauopathy Neuroimaging Initiative, ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2), Validating remote digital assessments for familial frontotemporal dementia, Frontotemporal Dementia: Genes, Images, and Emotions, Passive digital phenotyping for capturing real-world neurobehavior in neurodegenerative disease, Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease, Translational Epidemiology - Training for Research on Aging and Chronic disease

OpenAlex ID: W4415713326

FWCI: 7.498

Cites: 40

Cited by: 2

Related to: 10