A guide to the apicomplexan cell cycle: endodyogeny and schizogony
Year: 2025
Type: review
Abstract: This review focuses on recent advances in the field of cell division of eukaryotic pathogens of the phylum Apicomplexa, a group of pathogens known for their diverse modes of cell division. We cover two topics - an organization and a regulation of the apicomplexan cell cycles - using models of Toxoplasma gondii tachyzoites and Plasmodium falciparum merozoites of the red blood cell stage. The review emphasizes differences and similarities between the conventional cell cycle of the parasite's host cells and apicomplexan cell cycles, and between binary and multinuclear divisions of Apicomplexa. Although many factors play a role in cell cycle regulation, we concentrated on the central cell cycle regulators, cyclin-dependent kinase complexes.
Source: Trends in Parasitology
Authors: Mrinalini Batra, Elena S. Suvorova
Institution: University of South Florida
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
OpenAlex ID: W4415721325