Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein–lipid coaggregates
Year: 2025
Type: article
Abstract: Ambroxol, a small molecule known to stabilise Glucocerebrosidase, can act directly on α-synuclein–lipid coaggregation into amyloid fibrils, a process associated with Parkinson's disease, by preventing the formation of early protein–lipid oligomers.
Source: Chemical Science
DOI: 10.1039/d5sc06116d
Institutions: University of Copenhagen, ETH Zurich, Institute of Biochemistry
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Eidgenössische Technische Hochschule Zürich, Novo Nordisk, Danmarks Frie Forskningsfond, Faculty of Health and Medical Sciences, University of Western Australia, Novo Nordisk Fonden, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet
OpenAlex ID: W4415730044