Work

Efficacy of Intravenous Butorphanol for Preventing Epidural-Related Maternal Fever (ERMF) During Epidural Labor Analgesia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Purpose: The purpose of this research was to investigate whether intravenous low dose of butorphanol (1mg) at the onset of epidural analgesia (EA) can reduce the incidence of ERMF during labor. Patients and Methods: , more than 37 weeks' gestation, singleton pregnancy, American Society of Anesthesiology physical status I-II, normal maternal temperature and fetal heart rate, cervical dilation ≤ 3 cm, having EA were included in this double blinded randomized placebo-controlled trial. Women were randomized to receive intravenous butorphanol 1mL (Butor group) versus sterile saline 1mL (Con group), respectively. The primary outcome was the incidence of ERMF. Secondary outcomes included maternal temperature, pain score, the consumption of analgesic drugs, maternal and neonatal outcomes related to delivery. Results: <0.05). No severe maternal or neonatal adverse effects were observed in all subjects. Conclusion: A low dose of butorphanol intravenously used at the onset of EA in women undergoing vaginal delivery could effectively reduce the incidence of ERMF. Butorphanol may serve as a potential intervention for preventing ERMF in future.

Source: Drug Design Development and Therapy

DOI: 10.2147/dddt.s547255

Authors: Yao Zhang, Xulin Chen, Shiqin Xu, Shanwu Feng, Caijuan Li

Institution: Nanjing Medical University

Language: English

Topic: Anesthesia and Pain Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836