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Scalable Synthesis of a Dual TLR7/8 Agonist via Highly Selective N 2-Alkylation of 1 H -Pyrazolo[4,3- d ]pyrimidine

Year: 2025

Type: article

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c04092

Authors: Kai-Jiong Xiao, Yingju Xu, Lu Chen, Zheng Wu, Wenzhi Fang, Steven P. Miller, Jingjun Yin

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: closed

OpenAlex ID: W4415735124

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Cites: 24

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