Work

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Year: 2025

Type: article

Abstract: , Mbz and irinotecan both inhibited tumor growth, but the combination did not significantly outperform Mbz alone. Flow cytometry of the resected mouse tumors indicated that Mbz promoted macrophage polarization from the M2 to M1 phenotype, suggesting that immune modulation may contribute to its anticancer effect. Mbz has features making it a candidate for repositioning into an anticancer drug and part of its effect may be mediated by macrophage modulation.

Source: Oncology Reports

DOI: 10.3892/or.2025.9014

Authors: Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren

Institutions: Uppsala University Hospital, Uppsala University

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cancerfonden, Akademiska Sjukhuset, Uppsala Universitet