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Clinical implications of using different methods for estimating kidney function in older hospitalised patients: creatinine, cystatin C, or both

Year: 2025

Type: article

Abstract: Cystatin C is an emerging alternative to creatinine for estimating kidney function. Formulae using cystatin C may more accurately reflect glomerular filtration rate than those based on creatinine. We prospectively evaluated the impact of formulae incorporating cystatin C for estimating the glomerular filtration rate (eGFR) in older inpatients. The eGFRs incorporating cystatin C predicted lower kidney function than predicted by creatinine, with more than 20% of patients receiving a new diagnosis of chronic kidney disease and possibly requiring drug dose adjustment.

Source: Internal Medicine Journal

DOI: 10.1111/imj.70228

Authors: Ramya D Rajkumar, Jack Robinson, Nicholas Mills, Darren M. Roberts

Institutions: UNSW Sydney, St Vincent's Hospital Sydney, The University of Notre Dame Australia, Royal Prince Alfred Hospital

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Royal Australasian College of Physicians, Division of Materials Research