The LGALS9 / miR ‐491‐5p Axis Regulates CD8 + T Cell Function and Inhibits the Progression of Gastric Cancer
Year: 2025
Type: article
Abstract: ABSTRACT Gastric cancer is a prevalent and clinically significant gastrointestinal malignancy worldwide. Gastric cancer is characterized by limited treatment efficacy and a high recurrence rate. In this study, we found that LGALS9 was highly expressed in gastric cancer and may contribute to disease progression by modulating the infiltration of CD8 + T cells. Genetic knockout of LGALS9 reversed T cell function, attenuated immunosuppression, and enhanced the cytotoxic activity of T cells to kill gastric cancer cells. Furthermore, miR‐491‐5p was identified as a potential suppressor in gastric cancer. The microRNA miR‐491‐5p regulated T cell‐mediated immunity by targeting and inhibiting LGALS9, which was similar to the effect of LGALS9 knockout. Overall, the key target LGALS9 and its inhibitor miR‐491‐5p represent promising potential for treating gastric cancer.
Source: Cancer Science
DOI: 10.1111/cas.70232
Authors: Wanzhong Huang, Wei Zheng, Dagao Zhu, Zhi Sun, Wei Lu, Jun Tao, Chen Liu, Liangliang Li, Yingli Zhou, Honghong Fan, Hong Tao, Wenjuan Li
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,600
Funder: Bengbu Medical College
OpenAlex ID: W4415742602