Work

Chemoprevention of hepatocellular carcinoma

Year: 2025

Type: article

Abstract: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and a leading cause of cancer-related deaths globally. Chronic liver disease (CLD), primarily due to viral hepatitis, alcohol use, and metabolic dysfunction-associated steatotic liver disease with steatohepatitis (MASLD/MASH), remains the major risk factor for HCC development. Chemoprevention, the use of medications or supplements to prevent or delay cancer, offers a compelling strategy to reduce HCC incidence, especially during the extended latency period between CLD onset and HCC progression. This review evaluates the current evidence for chemopreventive strategies for HCC, including immunizations, pharmacologic therapies, and dietary supplements.

Source: Hepatology Communications

DOI: 10.1097/hc9.0000000000000836

Authors: Sara Schwenk, David E. Kaplan

Institutions: University of Pennsylvania, Philadelphia VA Medical Center

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700