Work

Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance

Year: 2025

Type: article

Abstract: Tardigrades survive extreme environments partly through the damage suppressor (Dsup) protein, which protects DNA from ionizing radiation and oxidative stress. Dsup is largely unstructured but binds nucleosomes to shield DNA from damage. To investigate its protective role in a whole organism, we expressed the Ramazzottius varieornatus Dsup gene in the nematode Caenorhabditis elegans . Transgenic worms tolerated x-ray exposure and oxidative stress without apparent toxicity and exhibited a notable extension of life span. This effect was independent of the canonical DAF-2/DAF-16 longevity pathway and mitochondrial dynamics. Instead, Dsup expression markedly reduced mitochondrial respiration, providing a plausible mechanism for enhanced oxidative stress resistance and extended longevity. Our findings demonstrate that Dsup can confer stress resistance and longevity benefits across species, highlighting a unique protective strategy with potential implications for understanding aging and developing stress-resilient organisms.

Source: Science Advances

DOI: 10.1126/sciadv.adx9669

Authors: Myriam Richaud, Rohit Shrivastava, Dimitris Xirodimas, Simon Galas, Aymeric Bailly

Institutions: École Nationale Supérieure de Chimie de Montpellier, Centre National de la Recherche Scientifique, Université de Montpellier, Institut des Biomolécules Max Mousseron, Centre de Recherche en Biologie cellulaire de Montpellier

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funder: Agence Nationale de la Recherche